The Application of Neutralizing Antibody in SARS-CoV-2 Infection
28

/Apr 2021

Summary

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic with millions infected. The immune responses of human body to the severe COVID-19 have been well studied, and a number of antibody-based assays have been developed for serological studies. Moreover, the study of the neutralizing antibody that targets at a special structural protein of the SARS-CoV-2 is of interest.

Infection by the SARS-CoV-2 or immunizedby vaccine against SARS-CoV-2 will induce immune responses, such as the production of antibodies in the blood. These antibodies can specifically bind with virus receptor binding domain (RBD) to block the binding of RBD with angiotensin-converting enzyme 2 (ACE2) on human cells surface, thus prevent the virus or its genetic material into the human cell and virus infection. These antibodies are named neutralizing antibodies.

In order to infect a human cell, SARS-CoV-2 utilizes S protein on its surface to bind to the human ACE2 receptor on the surface of human cells. Upon entry into the cell, the virus replicates causing the immune system to respond by producing different types of antibodies. These include virus-neutralizing antibodies (NAbs) which are crucial to protect the human body from future infections.

The SARS-CoV-2 neutralizing antibodies are protective antibody produced by the human body after inoculation with novel coronavirus vaccine or infection with novel coronavirus.

Getein Test Kit for SARS-CoV-2 Total Antibody /Neutralizing Antibody

Getein Biotech test kits for the detection of SARS-CoV-2 Neutralizing Antibody is intended for in vitro qualitative detection of SARS-CoV-2 neutralizing antibody in serum, plasma or whole blood samples. The test is only used for professional and laboratory use, not for home testing.

Getein One Step Test for SARS-CoV-2 Total Antibody/ Neutralizing Antibody is intended for in vitro qualitative detection of SARS-CoV-2 neutralizing antibodies in human serum, plasma, venous whole blood or fingertip blood. The kit is used to monitor the presence of neutralizing antibodies in subjects vaccinated with the novel coronavirus vaccine or in people infected with the novel coronavirus, it can be used to evaluate the immune effect after vaccination or whether neutralizing antibodies are produced in human body after infection with novel coronavirus, it should not be used to diagnose acute SARS-CoV-2 infection.


More info please check: www.gp-diagnostics.com


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